BackgroundResearch on prevalence of cognitive frailty phenotypes in community-dwelling older adults in different countries is important to estimate their prevalence and to determine the influence of cognitive reserve and mental health in order to prevent frailty. The aims of this study were to estimate the prevalence of reversible and potentially reversible cognitive frailty in a Portuguese sample of old adults and explore the associations between these phenotypes and demographic, comorbidity, social support, cognitive reserve and mental health factors.MethodsWe assessed frailty in (...) 250 community-dwelling older adults aged 60 years or over without dementia, neurological or psychiatric disorders. Subjective cognitive decline and Mild cognitive impairment were diagnosed according to standard criteria. The questionnaires Charlson Index, Medical Outcomes Study Social Support, Cognitive Reserve Index and General Health were used for assessing comorbidity, social support, cognitive reserve and mental health, respectively.ResultsPrevalence of R-CF was 14%, and that of PR-CF, 15.2%. Cognitive frailty profiles differed significantly in relation to education, comorbidity, mental health, and cognitive reserve, but not in age or sex. Multivariate logistic regression showed that age, sex, comorbidity, social support, mental health, and cognitive reserve together predicted R-CF and PR-CF with significant OR for mental health and cognitive reserve.DiscussionCognitive reserve and mental health are important factors predicting R-CF and PR-CF. We recommend assessing these factors for early detection of cognitive frailty and promoting psychological well-being and lifestyles that increase cognitive reserve in adults. (shrink)

IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...) A+T++ groups, spreading toward the parietal and frontal regions in A+T++ patients. These structural changes allowed distinguishing AT profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.ConclusionsMRI is useful in the determination of the specific brain structural changes of AT profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers. (shrink)

Tarski algebras, also known as implication algebras or semi-boolean algebras, are the \-subreducts of Boolean algebras. In this paper we shall introduce and study the complete and atomic Tarski algebras. We shall prove a duality between the complete and atomic Tarski algebras and the class of covering Tarski sets, i.e., structures \, where X is a non-empty set and \ is non-empty family of subsets of X such that \. This duality is a generalization of the known duality between sets (...) and complete and atomic Boolean algebras. We shall also analize the case of complete and atomic Tarski algebras endowed with a complete modal operator, and we will prove a duality for these algebras. (shrink)

Contiene tres trabajos sobre Arturo Ardao: sobre la noción de sujeto (Yamandú Acosta); sobre la interpretación de Andrés Bello (Arturo A. Roig); y sobre su libro Filosofía de lengua española (ver HLAS 36:5047). Mencionamos algunas de las otras contribuciones: el tema de la historia de la filosofía latinoamericana (Horacio Cerutti Guldberg); el batllismo (Manuel A. Claps); el tema de Calibán (Roberto Fernández Retamar); el pensamiento de Pedro Figari (Juan Fló); la universidad latinoamericana en el siglo XVIII (Gregorio Weinberg); (...) el pensamiento socialista en el Uruguay (Carlos Zubillaga). Es de lamentar que no se agregara al volumen una bibliografía de Ardao"--Handbook of Latin American Studies, v. 58. (shrink)

From the first books published by Jean-Paul Sartre, it is possible to observe the criticism that the French author makes to the Western metaphysical tradition, directed specifically at philosophers of modernity. For example, L'imagination and L'Imaginaire are two texts dedicated to questioning “the great metaphysical systems”. Furthermore, in these early investigations, Sartre discovers a principle that would allow him to elabo- rate his work Being and nothingness. What is this principle? The main objective of this essay is to determine this (...) principle and its importance in the elaboration of Being and nothingness. In order to achieve this purpose, I will analyze Sartre's criticism of modern philosophers (Descartes and Hume) and his proposal to overcome what Sartre himself calls: the “naive metaphysics of the image” (1978, p. 9), which is nothing more than the fact of reifying the image. (shrink)

The formulacognomen + nomen, as portrayed inLatronis enim Porcii(Sen.Controv. 1praef. 13), the first double-name reference withoutpraenomenin Seneca the Elder's work (henceforth referred to simply as Seneca), emerged as a result of the radical changes which the Roman onomastic system began to experience at the end of the Republic. On account of a wide variety of factors, both social and linguistic, thecognomenseized the role of diacritic name and individual signifier, having oustedpraenomenfrom its ancient throne; the relatively limited number ofpraenominain common use (...) contributed substantially to their waning. The formulae of two constituents visibly reflected the progressive decline ofpraenomina; during the Early Principate double names still represented the usual formal means of reference (tria nominabeing highly formal, mostly occurring in official contexts), but it mostly consisted ofnomen + cognomenrather thanpraenomen + nomenorpraenomen + cognomen. The formulanomen + cognomen, which developed once personalcognominabegan to spread among the lesser classes, was primarily crafted for addressing men of ambiguous status,peregriniand freedmen. Thus, Cicero tends to avoid its use in naming members of the nobility, whom he refers to with a clear preference for the older, lustrous conjunctionpraenomen + cognomen. (shrink)

El autor trabaja en este artículo una de las obras más citadas y controvertidas del Hegel de su periodo maduro cual es los Principios de la Filosofía del Derecho o Derecho Natural y Ciencia Política, comúnmente conocida como Filosofía del Derecho y desarrolla algunos temas que permanecen como cuestiones abiertas al debate o como aspectos objetables, tanto en su teoría del espíritu objetivo como en su interpretación.

Desde inicios del siglo xx la filosofía parecía haber despachado la legitimidad del realismo, llamando a la descripción del mundo dentro de los límites de nuestra subjetividad. El agotamiento y los problemas de esta premisa filosófica han sido finalmente enunciados y señalados por el realismo especulativo. En el presente artículo mostramos de qué manera tres de sus representantes más reconocidos, Meillassoux, Harman y Gabriel, llevan a cabo esta tarea. Pero para evitar una posición ingenua, este realismo se expresa de forma (...) especulativa, es decir, a partir de argumentos lógicos, matemáticos y abstractos que no carecen de problemas. Después de una breve exposición de sus filosofías, presentamos problemas centrales en ellas que se derivan de una falta de reflexión sobre los recursos lógicos y matemáticos que emplean explícita o implícitamente. Mostramos que la constante en todos ellos consiste tanto en un desconocimiento de las paradojas de autorreferencia que ponen en juego, como en la falta de una teoría de relaciones reales que explique las relaciones sujeto-objeto y objeto-objeto. Concluimos con una breve referencia a Fréredic Nef para mostrar qué puntos debería considerar una teoría general de relaciones. (shrink)

El autor sigue a Ana Arendt para examinar el tema de la responsabilidad personal bajo dictadura. Ante el argumento de que no había opciones pues se era una ‘ruedecilla del engranaje’, afirma que el mal menor no deja de ser un mal, y que la verdadera pregunta moral no es ‘por qué obedeciste’ sino ‘por qué ayudaste’.

Interest in the intersection between bilingualism and cognitive control and accessibility to neuroimaging methods have resulted in numerous studies with a variety of interpretations of the bilingual cognitive advantage. Neurocomputational Emergentism (or Neuroemergentism for short) is a new framework for understanding this relationship between bilingualism and cognitive control. This framework considers Emergence, in which two small elements are recombined in an interactive manner, yielding a non-linear effect. Added to this is the notion that Emergence can be captured in neural systems (...) using computationally inspired models. This review poses that bilingualism and cognitive control, as examined through the Neuroemergentist framework, are interwoven through development and involve the non-linear growth of cognitive processing encompassing brain areas that combine and recombine, in symbiotic and parasitic ways, in order to handle more complex types of processing. The models that have sought to explain the neural substrates of bilingual cognitive differences will be discussed with a reinterpretation of the entire bilingual cognitive advantage within a Neuroemergentist framework incorporating its neural bases. It will conclude by discussing how this new Neuroemergentist approach alters our view of the effects of language experience on cognitive control. Avenues to move beyond the simple notion of a bilingual advantage or lack thereof will be proposed. (shrink)

Oportuna reedición de una obra clásica sobre el pensamiento en Uruguay antes de la creación de la Universidad de la República (1849). Esta edición tiene aumentado el apéndice documental"--Handbook of Latin American Studies, v. 58.

Inspired by Columbus, Spaniards set out on an adventurous voyage of the circumnavigation of the globe and, to their surprise, encountered a new continent.This is the essential fact. There were no preliminaries, no previous knowledge, but an abrupt and unexpected meeting between a handful of men who represented the mentality of Spain at the end of the 15th century and an immense geographical panorama that slowly and continuously unfolded, populated by beings for whom there was not even a name and (...) who represented native cultures in different stages of devopment with no previous contact with Europeans, almost diametrically opposed in values, concepts and mentalities to what the transatlantic navigators represented and brought with them. (shrink)

The article explores some aspects of the intellectual climate of the first half of the nineteenth century and the new ideas about race and national identity. These in turn help to explain contemporary changes in historical perspective, particularly in respect to the English Reformation. Disraeli‘s novels reflect the ideas of the time on the above topics and echo contemporary historians in their views on the Reformation, its causes, and the religious and social changes that it brought about.

The contribution describes some aspects related to the representation of special curves; recalling mechanisms created specifically for the design of these curves, which have particular characteristics. Through the construction of a simple apparatus, consisting of two pendulums—which oscillate at the same time- it is possible to graphically reproduce Lissajous’ experiments on the commuting vibrations of the diapasons. This equipment was first built by Samuel Charles Tisley (London 1829-Unknown), under the name of harmonographer. The contribution aslo illustrates the essential characteristics of (...) the harmonograph—born as a means of analysing vibrations—but which, by its principle belongs to mechanics, for its applications to acoustic science and geometry for the ability to draw “harmonious” curves. (shrink)

En sus primeros escritos fenomenológicos, Jean-Paul Sartre sostiene la tesis de que la conciencia es exterioridad pura, es decir, no existe interioridad en la conciencia que pudiese albergar instancias metafísicas, como lo podría ser el yo, el cogito, el inconsciente, etc. Ya para El ser y la nada, el filósofo francés mantendrá dicha tesis, profundizándola y estableciendo un diálogo con su teoría del ser. En esta medida, el artículo se propone explorar tal relación, para conocer el lugar que ocupa la (...) noción de conciencia en el Ser y la nada. (shrink)

This paper examines how international law contributes to contemporary understandings of transitional justice with respect to reparations for victims of gross and systematic human rights abuses. The author surveys the jurisprudence of the Inter-American Court of Human Rights through 2003 to determine how the Court’s practice can be used to guide the formulation of reparatory policies during political transition. Recognizing that the direct application of Inter-American case law to situations of mass atrocity is not always viable in practice, the author (...) analyzes regional human rights jurisprudence, particularly that relating to compensation, to determine what role the Court’s rules can and cannot play as a reference for policymakers and societies faced with the challenge of designing a reparations program. He concludes that while landmark Court decisions like Velásquez Rodríguez provide general normative guidance, there are significant obstacles to extending to the transitional justice context many of the measures, amounts, and formulas relied upon by the Court in awarding compensation. The fairness of compensation outside the courtroom cannot be determined with reference to predetermined rules, but depends on the factual context in which the measures are adopted including the number of victims involved. A better source of comparative inspiration is found in the Court’s growing practice of adopting non-monetary reparations measures to deal with moral harm. (shrink)

The settler-colonial and republican principles of early U.S. politics tend to be studied as paradoxical ambitions of American nation-building. This article argues that early republican thought in the United States developed through what I call ‘ideological code-switching’, a vernacular practice that allowed popular actors to strategically vacillate between anti-colonial and neo-colonial discourses as complementary principles of revolutionary change. I illustrate these claims by tracing a genealogy of anti- and neo-colonial thought from the founding of the United States to its transnational (...) emergence in the U.S.-Mexico borderlands. I demonstrate that ideological code-switching first appeared as a rhetorical strategy among the Federalist debates, where Publius argued for the feasibility of expansionist republics via a hemispheric account of American exceptionalism. These appeals to hemispheric unity remained salient into the nineteenth century among groups like the ‘Republicans of ‘Nacogdoches’, a militia comprised of Indigenous, Mestizo, and White actors that mobilized an attack on Spain and founded the Republic of Texas in April of 1813. Drawing on archival research, I turn to the U.S.-Mexico borderlands as an example of the way marginalized groups instrumentalized links between anti- and neo-colonial politics to envision their position in the rapidly evolving landscapes of transnational revolution. (shrink)

This essay has two goals. The first is to define the behavioristic study of natural events and to classify behavior. The second is to stress the importance of the concept of purpose.Given any object, relatively abstracted from its surroundings for study, the behavioristic approach consists in the examination of the output of the object and of the relations of this output to the input. By output is meant any change produced in the surroundings by the object. By input, conversely, is (...) meant any event external to the object that modifies this object in any manner. (shrink)

Con una belleza literaria incomparable, la Comedìa refleja la cosmovisión católica que vertebra la Cristiandad medieval, que tuvo su máximo exponente filosófico y teológico en santo Tomás. A lo largo de todo el itinerario poético, vemos la impronta del Aquinate presente en el meollo de la narración. Aquí analizaré cómo la cuestión teológica fundamental del gobierno divino del mundo permea la Comedìa, tanto en su estructura formal como en ciertos aspectos concretos del viaje de Dante. A partir de dicha premisa, (...) estudiaré las consecuencias que ello tiene en ese orden jurídico manifestado en la «arquitectura» del infierno, cuyo dintel es elocuente: «Giustizia mosse il mio alto fattore; / fecemi la divina podestate, / la somma sapienza e ‘l primo amore». Finalmente, abordaré la proporcionalidad de las penas que sufren los condenados, como indicador de la medida natural de los castigos dictados por justicia divina. (shrink)

La percepción puede proponerse como uno de los factores centrales que propician el inicio de procesos semiósicos. La complejidad de esta primera fase cognitiva exige una perspectiva trans e interdisciplinar. Así, desde una postura biosemiótica, trataremos de proponer uno de los conceptos centrales de esta novel teoría, a saber, ‘biosemiosis’. Para ello, nos apoyaremos en ciertos experimentos emanados de las neurociencias. Esta vinculación, en la actualidad, ya no debe resultar extraña si comprendemos que, en nuestro caso, el ser humano es (...) una entidad compuesta por dos esferas fundamentales: la biológica y la cultural. Nos encontramos en un momento en el que el Universo puede entenderse como una enorme red interconectada. Así, la cooperación entre diferentes campos del conocimiento permitirá una mejor comprensión de dichas redes. (shrink)

La polarización, los populismos y la posverdad forman tres fenómenos sociopolíticos fundamentales para comprender cómo se está orientando la política en los sistemas demoliberales. La polarización política se suele entender como un proceso dinámico de activación de las divisiones entre dos o más grupos sociales en el transcurso de los debates públicos que puede terminar con una ruptura comunicativa o una comunicación fallida. Si bien los especialistas no coinciden a la hora de definir el populismo, se puede comprender como una (...) forma concreta de construir el pueblo mediante un discurso que contrapone este al anti-pueblo. La posverdad se referiría a una tendencia cultural donde las verdades de hecho sufren una merma en favor de las verdades vivenciadas subjetivamente. Estos fenómenos tienden a ser percibidos por una buena parte de la sociedad y del mundo académico como una amenaza grave para las bases pluralistas y reflexivas de la democracia. Sin embargo, esa consideración está decantada normativamente. Este artículo trata de explorar un marco referencial diferente, el emotivismo, y cómo, desde este ángulo, toman sentido los tres conceptos clave: polarización, populismo y posverdad. (shrink)

This chapter contains sections titled: References.

El interés por caracterizar la noción del entendimiento científico es relativamente nuevo, no obstante que el término ha sido ampliamente utilizado en la literatura científica y filosófica, sin mencionar muchas otras. Como aportación a las investigaciones actuales sobre esta noción, el objetivo del siguiente escrito es presentar un análisis crítico de la relación entre el entendimiento científico y las emociones.

In the context of life sciences, we are constantly confronted with information that possesses precise semantic values and appears essentially immersed in a specific evolutionary trend. In such a framework, Nature appears, in Monod’s words, as a tinkerer characterized by the presence of precise principles of self-organization. However, while Monod was obliged to incorporate his brilliant intuitions into the framework of first-order cybernetics and a theory of information with an exclusively syntactic character such as that defined by Shannon, research advances (...) in recent decades have led not only to the definition of a second-order cybernetics but also to an exploration of the boundaries of semantic information. As H. Atlan states, on a biological level "the function self-organizes together with its meaning". Hence the need to refer to a conceptual theory of complexity and to a theory of self-organization characterized in an intentional sense. There is also a need to introduce, at the genetic level, a distinction between coder and ruler as well as the opportunity to define a real software space for natural evolution. The recourse to non-standard model theory, the opening to a new general semantics, and the innovative definition of the relationship between coder and ruler can be considered, today, among the most powerful theoretical tools at our disposal in order to correctly define the contours of that new conceptual revolution increasingly referred to as metabiology. This book focuses on identifying and investigating the role played by these particular theoretical tools in the development of this new scientific paradigm. Nature "speaks" by means of mathematical forms: we can observe these forms, but they are, at the same time, inside us as they populate our organs of cognition. In this context, the volume highlights how metabiology appears primarily to refer to the growth itself of our instruments of participatory knowledge of the world. (shrink)

In 1985, when I graduated from medical school, I thought that medicine in 2018 would be more advanced than it is today. Coloring that view were the dizzying medical advances made from 1950 to 1980, three decades that were Figure 1 Major biomedical advances as a function of the time perhaps the most innovative period in modern medicine. Recent times have seen fewer revolutionary advances, although remarkable progress continues to be made in certain areas, including imaging of disease, the treatment (...) of retroviral infections such as those caused by HIV and hepatitis C virus, nucleic acid-based diagnostics, and cancer immunotherapy. The critical question is not whether we are continuing to make progress... (shrink)

Technology development and innovation are fundamentally different from scientific research. However, in many circumstances, they are evaluated jointly and by the same processes. In these cases, peer review—the most usual procedure for evaluating research—is also applied to the evaluation of technological products and innovation activities. This can lead to unfair results and end up discouraging the involvement of researchers in these fields. This paper analyzes the evaluation processes in Uruguay's National System of Researchers. In this system, all members' activities, both (...) scientific and technological, are evaluated by peer committees. Based on documentary analysis and semi-structured interviews, the difficulties faced by evaluators in assessing technology products are explored. The article highlights the persistence of a linear conception of the link between science and technology and describes the obstacles to assimilate the particularities of technological activities. Refereed publications are presented as the only uncontested product. Other types of output are reviewed with suspicion. This study emphasizes the need for specific mechanisms to evaluate technological production within academic careers. (shrink)

Original, or 'old', institutional economics (OIE) – also known as 'institutionalism' – played a key role in its early stages; it could be said that it was once the 'mainstream economics' of the time. This period ran approximately from the first important contributions of Thorstein Veblen in 1898 to the implementation of the New Deal in the early 1930s, where many institutionalists played a significant role. However, notwithstanding its promising scientific and institutional affirmation, institutional economics underwent a period of marked (...) decline that spanned from the mid-1930s to the late 1980s, when a new season for institutional economics was set in motion. In order to cast some light on this complex issue – without any claim of completeness – we have organised the work as follows: in the first section we consider the main interpretations of this phenomenon. In the subsequent sections we analyse a number of 'endogenous' aspects which might have played a significant role in the period of decline: (i) the relations of institutional economics with Keynes's macroeconomic theory; (ii) the links between theoretical and empirical analysis and the supposed lack of a clear theory; (iii) the interdisciplinary orientation. (shrink)